BY TEENA CHOPRA, MD, MPH, MATHEW LEPERA, DO, AND GLENN TILLOTSON, PhD BACKGROUND Clostridioides difficile (C. difficile) infection is the number one cause of hospital-acquired diarrhea. Additionally, it is increasingly a cause of gastrointestinal illness in the community, with more than one-third of all U.S. infections occurring outside the hospital setting. There are approximately…